Ray Romano as Manfred (voice); John Leguizamo as Sid (voice); Denis Leary as Diego (voice); Goran Visnjic as Soto (voice); Jack Black as Zeke (voice); Cedric the Entertainer as Carl (voice); Stephen Root as Rhino/Start (voice); Diedrich Bader as Saber-Toothed Tiger (voice); Alan Tudyk as Oscar/Dab the Dodo (voice); Lorri Bagley as Female Sloth (voice)

Irene Escolar as Eurydice; Fernando Tielve as Orfeo/Enrico; Hector Bordoni as Pedro August?n; Antonio Banderas as Carlos Rueda; Emma Thompson as Cecilia Rueda; Maria Canals as Esme Palomares; Rubén Blades as Silvio Ayala; Leticia Dolera as Teresa Rueda; Luis Antonio Ramos as Policeman 2; Carlos Caniowski as Rubén Mendoza (as Carlos Kaniowski)

Irene Escolar as Eurydice; Fernando Tielve as Orfeo/Enrico; Hector Bordoni as Pedro August?n; Antonio Banderas as Carlos Rueda; Emma Thompson as Cecilia Rueda; Maria Canals as Esme Palomares; Rubén Blades as Silvio Ayala; Leticia Dolera as Teresa Rueda; Luis Antonio Ramos as Policeman 2; Carlos Caniowski as Rubén Mendoza (as Carlos Kaniowski)

Bruce Willis as Emmett Smith; Emily Lloyd as Samantha Hughes; Joan Allen as Irene; Kevin Anderson as Lonnie; John Terry as Tom; Peggy Rea as Mamaw; Judith Ivey as Anita; Daniel Jenkins as Dwayne; Stephen Tobolowsky as Pete; Jim Beaver as Earl Smith

Dennis Hopper as Narrator (voice); Peter Bart as Himself; Warren Beatty as Himself (archive footage); Carl Bernstein as Himself; Tony Bill as Himself; Ralph Blumenthal as Himself; Barbara Boreman as Herself; Helen Gurley Brown as Herself; Susan Brownmiller as Herself; Lenny Camp as Himself

Al Pacino as Detective Will Dormer; Martin Donovan as Detective Hap Eckhart; Robin Williams as Walter Finch; Oliver 'Ole' Zemen as Pilot; Hilary Swank as Detective Ellie Burr; Paul Dooley as Chief Charlie Nyback; Nicky Katt as Fred Duggar; Larry Holden as Farrell; Jay Brazeau as Francis; Lorne Cardinal as Rich

Tom Cruise as Lestat de Lioncourt; Brad Pitt as Louis de Pointe du Lac; Kirsten Dunst as Claudia; Stephen Rea as Santiago; Antonio Banderas as Armand; Christian Slater as Daniel Malloy; Virginia McCollam as Whore on Waterfront; John McConnell as Gambler; Mike Seelig as Pimp; Bellina Logan as Tavern Girl

Tom Cruise as Lestat de Lioncourt; Brad Pitt as Louis de Pointe du Lac; Kirsten Dunst as Claudia; Stephen Rea as Santiago; Antonio Banderas as Armand; Christian Slater as Daniel Malloy; Virginia McCollam as Whore on Waterfront; John McConnell as Gambler; Mike Seelig as Pimp; Bellina Logan as Tavern Girl

Vin Diesel as Richard B. Riddick; Lisa Saum as Femme-Merc; Brian Gant as Lawman; Robert Ahola as Prison Guard; Andrew Bernard as Search and Rescue #1; Jorge Berrio as Prison Guard #1; Kevin Burnett as Cutter; Markus Hamilton as Mr. Kammal; Alistair Love as Prison Guard #2; Danny Miller as Computer (voice)

Nicolas Cage as Charlie Lang; Bridget Fonda as Yvonne Biasi; Rosie Perez as Muriel Lang; Wendell Pierce as Bo Williams; Isaac Hayes as Angel Dupree; V?ctor Rojas as Jesu; Seymour Cassel as Jack Gross; Stanley Tucci as Eddie Biasi; J.E. Freeman as Sal Bontempo; Red Buttons as Walter Zakuto